Design for Peptide Delivery
Quickly commercializing safe and effective products to benefit patients and improve quality of life is the charter of most pharmaceutical and medical device companies. Many drugs, and in particular peptide therapeutics, benefit from controlled delivery systems. While these delivery systems can significantly improve the therapeutic product, peptides are not typically screened or optimized for properties that would allow more effective implementation in controlled delivery systems. In the cases where controlled delivery offers significant advantages, this inevitably results in delays during formulation development which could be avoided by simply choosing or designing the peptide with controlled delivery in mind.
Design for Peptide DeliverySM is a solution-oriented approach which addresses peptide formulation issues early during development by screening lead compounds or assessing drug development candidates for their ability to be effectively implemented in proven drug delivery systems. Proven drug delivery technologies, having gone through the rigors of safety testing, regulatory review, product approval, and demonstrated market acceptance are greatly preferred to quickly advance the product to market. Using the Design for Peptide DeliverySM strategy, the Brookwood - Genzyme team performs drug delivery-based screening on lead peptides in discovery to provide the optimum peptide for use in controlled delivery. Brookwood - Genzyme also support your peptide lead optimization efforts with design input for enhanced formulation compatibility and thus drugability.
Come to us to perform Design for Peptide DeliverySM screening or optimization, so your peptides match:
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Formulation manufacturing parameters
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Release kinetics needed
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Formulation stability required
As an example, we use a variety of building blocks to construct a successful formulation by optimizing the properties of both the polymer and the matrix. While this approach provides a significant number of opportunities to produce a controlled release formulation, building blocks for one of the most significant components, the peptide, are not used typically used.
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Using Design for Peptide DeliverySM, a number of new blocks become available such as: peptide solubility, peptide counterion, peptide hydrophobicity, peptide bulk density, thermal stability, peptide charge, etc. The peptide stability and its physical properties are interdependent parameters impacting formulation processing, formulation stability and release kinetics:
With Design for Peptide DeliverySM screening, we can identify early on the peptide candidates with the best properties for drug delivery. Or, optionally, we can optimize a peptide lead compound to match the delivery system. Brookwood - Genzyme has access to a wide range of tools for adjusting the physical, physico-chemical and – if necessary – chemical properties of a peptide to achieve a best possible match. A minor modification such as the simple substitution of a counter ion may be sufficient to effectively modulate delivery parameters without affecting biological activity of the peptide.
The Brookwood - Genzyme Pharmaceuticals Collaboration offers customers a solution-oriented approach to peptide formulation through synergistic capabilities and technologies, depending on the peptide and the customer's target drug profile.